SNIC SUPR
Genomic Analysis of Enhancer Elements
Dnr:

SNIC 2019/8-20

Type:

SNIC Small Compute

Principal Investigator:

Kashyap Dave

Affiliation:

Karolinska Institutet

Start Date:

2019-01-16

End Date:

2020-02-01

Primary Classification:

30401: Medical Biotechnology (focus on Cell Biology (incl. Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy)

Webpage:

Allocation

Abstract

F-box/WD repeat-containing protein 7 (FBWX7) gene has three isoforms which are selectively expressed in different cancer type. Preliminary data indicates towards differential usage of genomic enhancers resulting in cancer-specific isoform expression. In this project I will explore, map and validate genomic enhancers that regulate cancer-specific isoform expression.