Hydrogen transfer methylation of ketones using methanol as the electrophile

Dnr:

SNIC 2015/4-60

Type:

SNAC Small

Principal Investigator:

Xu Quan

Affiliation:

Stockholms universitet

Start Date:

2015-11-05

End Date:

2017-12-01

Primary Classification:

10405: Organisk kemi

Webpage:

http://www.organ.su.se/pga/index.html

Allocation

Abstract

N-heterocyclic carbenes, when compared to their phosphine analogues, offer stronger metal–ligand bond formation and better stability properties. The N-heterocyclic carbene iridium complex was found to be the first catalyst to be used at room temperature with low catalyst loading. In these transition-metal catalyzed hydrogen transfer reactions the mechanism is as follows: the catalyst removes the hydrogen atoms from an alcohol to generate an aldehyde, which undergoes bond formation with another nucleophile in a condensation reaction, after which the metal hydride formed from the oxidation of the alcohol reduces this newly generated intermediate to give the final product. The simplest alcohol: methanol is an important compound in the chemical industry, and its transition-metal catalyzed dehydrogenation has been described previously and report on the potential application of methanol in C-C bond formation via hydrogen transfer reactions. The aim of this study is to perform a quantum-chemical investigation in order to reveal the reaction mechanism and hence to understand the selectivity process of the catalyst in this reaction.