Bone mechanics at the microscale

SNIC 2016/7-7


SNAC Small

Principal Investigator:

Per Isaksson


Uppsala universitet

Start Date:


End Date:


Primary Classification:

20301: Teknisk mekanik




We are using high-resolution FE computational models to analyse mechanical properties and fracture behavior of human bone tissues. The structural geometries, i.e. meshes, are directly obtained from high-resolution synchrotron X-ray images. The overall aim of the project is to improve synthesis and processing of ceramic-based bone cements, to achieve high-strength cements, possibly composites, adequate for use in load-bearing applications. This will permit a substitution of the less biocompatible acrylic-based cements in the clinics and/or a decreased number of painful and costly reoperations, associated to the low mechanical properties of today’s ceramic cements. Specifically, we aim to: • Develop a stronger base ceramic cement • Develop mechanical models of fluid and solid polymer-reinforced ceramic cements • Develop a ceramic-polymer composite, intended for biomedical applications • Develop a delivery technique for the new cements • Evaluate the novel cements in existing and novel applications at a bench-test level, namely through injection into bone as well as in the development of patient-specific skull implants