Functional characterisation of enhancer sequences

Dnr:

SNIC 2016/7-108

Type:

SNAC Small

Principal Investigator:

Pelin Sahlén

Affiliation:

Kungliga Tekniska högskolan

Start Date:

2016-10-20

End Date:

2018-11-01

Primary Classification:

10610: Bioinformatik och systembiologi (metodutveckling under 10203)

Webpage:

Allocation

Abstract

In this project we will attempt to characterise enhancers using chromatin marks and transcription factor binding motifs they contain as well as expression levels of genes they regulate. We generated a genome-wide map of promoter-anchored interactions for a well-define cell type which plenty of public chromatin datasets are available. We will overlay our promoter-enhancer interaction data with public datasets to characterise enhancer sequences and if possible predict expression patterns of genes they regulate.