Development of microfluidic devices for cell separation

Dnr:

SNIC 2016/3-76

Type:

SNAC Small

Principal Investigator:

Krister Wiklund

Affiliation:

Umeå universitet

Start Date:

2016-12-14

End Date:

2018-01-01

Primary Classification:

10399: Annan fysik

Webpage:

http://www.physics.umu.se/english/research/biological-physics/the-biophysics-and-biophotonics-group/

Allocation

Abstract

This project is a part of the work in the Biophysics group at department of physics, Umeå University, and aims to investigate the hydro-dynamical effects on cells in microfluidic devices. Due to the complexity of the equations describing the behavior of cells in fluid flows numerical simulations are necessary. In addition to the forces from the fluid the cell’s interaction with walls has to be considered and this makes the simulation problem even harder. Until now the 3D microfluidic simulations have been performed on a standard pc but in the upcoming tests the accuracy we need to resolve the fluid-cell-wall interaction requires more computational power and RAM-memory. The simulations will result in a designs of microfluidic devices that will be compared to experiments on real channel flows performed in the Bipphysics group and the aim is to develop new and more effective microfluidic devices for separation of cells with different properties, for example separation of cancer cells from blood using the fact that cancer cells have other hydro-dynamical properties compared to healthy cells.