Impact of alignment filtering on phylogenies

Dnr:

SNIC 2016/7-130

Type:

SNAC Small

Principal Investigator:

Marcin Bogusz

Affiliation:

Uppsala universitet

Start Date:

2016-12-14

End Date:

2018-01-01

Primary Classification:

10615: Evolutionsbiologi

Webpage:

Allocation

Abstract

Multiple sequence alignment (MSA) filtering is a common step prior to phylogenetic analyses. There's at least a dozen of filtering tools, each claiming to perform well under various circumstances. In this project we're looking at the impact of the filtered alignments on resulting phylogenetic tree topologies using simulated data. We suspect that in most of the cases trees will not be bettered than the ones obtained from unfiltered MSAs. We'll account for sampling errors by simulating long alignments.