RNA Editing in lymphoma

Dnr:

SNIC 2017/7-19

Type:

SNAC Small

Principal Investigator:

Mohammad Pirmoradian

Affiliation:

Karolinska Institutet

Start Date:

2017-02-02

End Date:

2018-03-01

Primary Classification:

30107: Medicinsk genetik

Webpage:

Allocation

Abstract

Diffused large B-cell lymphoma (DLBCL) is the most common and aggressive subtype of B-cell non-Hodgkin lymphoma. DLBCLs are highly heterogeneous both phenotypically and at the molecular level. RNA editing as a post-transcriptional modification enhances the diversity of gene products and the regulation of the expression profile, and can have important roles in desease progression such as cancer. We have acquired the genomic DNA sequences and transcriptomic RNA sequences for 183 samples from our lymphoma patient cohort. Analyzing this dataset, we are going to explore the role of RNA editing in the progression of the DLBCL as well as Follicular lymphoma (FL).