Determinants of serotonergic identity

Dnr:

SNIC 2017/7-24

Type:

SNAC Small

Principal Investigator:

Johan Holmberg

Affiliation:

Karolinska Institutet

Start Date:

2017-02-07

End Date:

2018-03-01

Primary Classification:

30108: Cell- och molekylärbiologi

Webpage:

Allocation

Abstract

The structural complexity of the adult brain is a major obstacle for gene regulation analysis in vivo. We are using a novel protocol for isolation of specific neuronal populations in order to investigate patterns of active and repressive histone modifications. Correlation of these ChIP-seq data with gene expression levels (RNA-seq) will elucidate the epigenetic landscape of neuronal gene regulation.