Mouse lymphoma proteogenomics

Dnr:

SNIC 2017/7-48

Type:

SNAC Small

Principal Investigator:

Erik Fredlund

Affiliation:

Karolinska Institutet

Start Date:

2017-03-09

End Date:

2018-04-01

Primary Classification:

30108: Cell- och molekylärbiologi

Webpage:

Allocation

Abstract

We have sequencing 31 mouse transcriptomes from radiation-induced T-cell lymphomas generated in an interspecific SpretusxMusculus backcross population. We have previously performed exome sequencing, as well as in depth MS/MS proteomics, giving relatively complete molecular profiles for our tumor cohort. The overall aim of the project is to perform a complete proteogenomic analysis of tumor development and progression. One part of this will be to analyze allele-specific mutation, expression and translation profiles.