Mouse lymphoma proteogenomics
We have sequencing 31 mouse transcriptomes from radiation-induced T-cell lymphomas generated in an interspecific SpretusxMusculus backcross population. We have previously performed exome sequencing, as well as in depth MS/MS proteomics, giving relatively complete molecular profiles for our tumor cohort. The overall aim of the project is to perform a complete proteogenomic analysis of tumor development and progression. One part of this will be to analyze allele-specific mutation, expression and translation profiles.