De novo assembling for chicken genome

Dnr:

SNIC 2017/7-53

Type:

SNAC Small

Principal Investigator:

Ying Guo

Affiliation:

Uppsala universitet

Start Date:

2017-03-15

End Date:

2018-04-01

Primary Classification:

10610: Bioinformatik och systembiologi (metodutveckling under 10203)

Webpage:

Allocation

Abstract

Pan-genome analysis is a strategy based on genome De novo sequencing and assembly that construct the Pan-map of the corresponding species. A Pan-genome facilitates the entire genetic information including gene sets, sequence variations, etc., which could help dig the causative mutations related to important traits and characterize the relationship between selection and molecular evolutionary history of each breeds. In order to build the Pan-genome of chicken, increase the understanding of the adaptation to selection, and analyze the causal genes and their functions in depth, we will combine De novo assembly with population-scale resequencing for studying the Pan-genome of 10 different chicken breeds including several comercial layers, broilers and Chinese domestic chickens which present various morphological traits. This work will illustrate the value of De novo assembly in building and characterizing chicken pan-genome, and provide candidate genes for both economic and morphological traits which would accelerate the progress of breeding and raise economic benefit.