Structural alterations in mitochondrial DNA in cancer

Dnr:

SNIC 2017/11-3

Type:

SNAC Large

Principal Investigator:

Erik Larsson

Affiliation:

Göteborgs universitet

Start Date:

2017-07-01

End Date:

2018-07-01

Primary Classification:

10610: Bioinformatik och systembiologi (metodutveckling under 10203)

Secondary Classification:

30107: Medicinsk genetik

Tertiary Classification:

30108: Cell- och molekylärbiologi

Webpage:

http://www.larssonlab.org/

Allocation

Abstract

The mitochondrial genome may display instability due to mutations in key components of the machinery the replicates mitochondrial DNA. This well-established in relation to disease-causing heritable mutations, but less is known about the role and scale of mitochondria DNA (mtDNA) instability in cancer. We want to analyze large volumes of cancer genomics data with respect to large deletions or duplication in mtDNA. A computational pipeline has been established and thoroughly evaluated. However, high-performance computing is needed to carry out the project on actual data. We will use publicly available sequencing data generated by The Cancer Genome Atlas and other efforts.