lncRNA_development

Dnr:

SNIC 2017/7-109

Type:

SNAC Small

Principal Investigator:

Hassan Foroughi Asl

Affiliation:

Karolinska Institutet

Start Date:

2017-07-12

End Date:

2018-08-01

Primary Classification:

10614: Utvecklingsbiologi

Webpage:

http://ki.se/en/mtc/claudia-kutter-group

Allocation

Abstract

Over 200 highly specialized cells with diverse morphologies and functionalities exist in the human body, yet virtually every cell in the body contains the same genetic information. To exert cell-specific functions high fidelity mechanisms restrict the expression and processing to only a certain set of genes and transcripts. Abnormal cell behavior as seen in many fatal human diseases, such as cancer, is often the consequence of aberrant transcripts formation. Recently developed deep sequencing technologies that allow measuring of the entire cellular transcript content revealed that up to 85% of the human genome is transcribed. Of those less than 3% encode for protein-coding genes and more than 97% for noncoding RNAs (ncRNAs). The recently discovered long ncRNAs (lncRNAs) represent a group of regulatory ncRNAs that act as potent modifiers of gene expression. The aim of this study is to identify ncRNAs during mouse organ development using RNA-sequencing and epigenetic profiling. *This project is an extension of b2016216. Due to slow filesystem on Milou, we are migrating from Milou to Rackham. [SNIC support #152508]