Maternal effects in risk of mental disorders

Dnr:

SNIC 2017/1-365

Type:

SNAC Medium

Principal Investigator:

Sven Sandin

Affiliation:

Karolinska Institutet

Start Date:

2017-09-07

End Date:

2018-10-01

Primary Classification:

10610: Bioinformatik och systembiologi (metodutveckling under 10203)

Webpage:

Allocation

Abstract

Project description: The goal of this project is to develop and apply computationally efficient models and tools to investigate the role of maternal effects in risk of mental disorders. Once these methods are developed, we apply them to estimate the additive genetic and maternal effect contributions in the etiology of obsessive-compulsive disorder (OCD), intellectual disability, and attention deficit hyperactivity disorder (ADHD). The study base stems from a population of over 15 million individuals using the Swedish Multi-Generation Register (MGR) data.