SNIC
SUPR
SNIC SUPR
Pneumococcal genomic and transcriptomic studies
Dnr:

SNIC 2017/1-550

Type:

SNAC Medium

Principal Investigator:

Birgitta Henriques-Normark

Affiliation:

Karolinska Institutet

Start Date:

2017-12-06

End Date:

2019-01-01

Primary Classification:

30109: Microbiology in the medical area

Allocation

Abstract

We study pneumococcal infection that are major contributors to morbidity and mortality world wide. New conjugated pneumococcal vaccines have been launched targeting only a minor proportion of pneumococcal strains circulating in the society. He we aim at studying the genomic content of pneumococcal strains as well as perform transcriptomic analyses on different conditions. We aim at investigating why certain non-vaccine pneumococcal strains/clonal types are emerging after vaccination.Hence we are sequencing a large collection of clinical isolates of pneumococci. The project includes several bioinformaticians and is a collaboration between professor Jens Lagergrens (KTH) and professor Birgitta Henriques Normarks (KI/KS) groups.