SNIC
SUPR
SNIC SUPR
COMPUTATIONAL PROJECT - CANINE CANCER
Dnr:

SNIC 2017/7-384

Type:

SNAC Small

Principal Investigator:

Kerstin Lindblad-Toh

Affiliation:

Uppsala universitet

Start Date:

2018-01-05

End Date:

2019-02-01

Primary Classification:

30107: Medical Genetics

Webpage:

Allocation

Abstract

Our group is part of an international effort that uses the dog as an experimental model to understand the pathological mechanisms involved in cancer. Dogs develop cancers spontaneously and the histopathological and clinical features of these tumors are largely similar to those in humans. However, the breed structure and the shorter life span of dogs makes it easier to perform genomic studies to understand the genetic predispositions to these cancers that have the same statistical power but can use a much smaller number of individuals than if the study would be performed in humans. Under this cumulative project we investigate different cancers such as: osteosarcoma, hemangiosarcoma, mammary tumors, etc. We would like to consolidate under this project all the data from the following projects currently on milou: b2012126 (Dog mRNA seq), b2014225 (Hem_D_IE), b2015117 (DOG_OSA_VDM), b2015314 (MCT_D_MLA), b2017226 (OSA_TN).