SNIC
SUPR
SNIC SUPR
Linking diversity and function of interneurons in zebrafish
Dnr:

SNIC 2018/8-202

Type:

SNAC Small

Principal Investigator:

Abdeljabbar El-Manira

Affiliation:

Karolinska Institutet

Start Date:

2018-06-01

End Date:

2019-06-01

Primary Classification:

30105: Neurosciences

Webpage:

Allocation

Abstract

The goal of our research is to understand how circuits in the brainstem and spinal cord control the versatility of motor actions using the zebrafish as a model system. Our recent results have revealed that the vigor of locomotor movements are controlled by three distinct circuit modules that control selectively the activity of slow, intermediate and fast muscles. We now seek to understand the molecular mechanisms underlying the functional diversity of interneurons and motoneurons using single-cell RNAseq. Zebrafish is the only vertebrate model system in which a direct link between neuronal diversity and function could be elucidate. Thus, this project will provide novel insights into the molecular mechanisms controlling diversity of circuits for motor actions and will also serve as a guide for studies in mammalian systems.