In this large scale computational project we develop and apply new multi-scale models and methods for soft and biological matter. We investigate the mechanisms how ionic liquids as additives in lubricants reduce the friction and wear. We compute transport properties such as viscosity and mass transport for ionic liquids and liquid crystals. We model and develop solvent-mediated coarse-grained models for canonical and non-canonical DNA structures and large DNA-protein assemblies The common point in all projects is the length of the scales but the challenges are different. All projects require extensive computing resources.