SNIC
SUPR
SNIC SUPR
Temporal Analysis
Dnr:

SNIC 2018/8-233

Type:

SNAC Small

Principal Investigator:

Ashwini Priya Jeggari

Affiliation:

Karolinska Institutet

Start Date:

2018-07-25

End Date:

2019-08-01

Primary Classification:

10614: Developmental Biology

Allocation

Abstract

Regulation of temporal specification of different neuronal types in the developing hindbrain. Transcriptional control of temporal decisions by master transcription factors Nkx2.2, Gli1, Phox2b and others. Neural progenitors derived from mouse ESCs were purified at different stages of the differentiation and RNA-seq, ChIP-sequencing were performed. From the obtained sequencing data, we want to analyze the binding profile of key transcription factors, gene expression profiles to understand the temporal mechanism of cell fate choice.