SNIC
SUPR
SNIC SUPR
Reference bias investigation
Dnr:

SNIC 2018/8-239

Type:

SNAC Small

Principal Investigator:

Carl Nettelblad

Affiliation:

Uppsala universitet

Start Date:

2018-08-10

End Date:

2019-09-01

Primary Classification:

10203: Bioinformatics (Computational Biology) (applications to be 10610)

Webpage:

Allocation

Abstract

Alignment of sequencing reads is done against a reference sequence. This puts mutations at an immediate disadvantage, biasing results. We aim to systematically compensate for this by verifying if the opposite allele is also detected.