SNIC
SUPR
SNIC SUPR
Joint analysis of bulk DNA and single cell RNA sequencing data
Dnr:

SNIC 2018/8-281

Type:

SNAC Small

Principal Investigator:

Seong-Hwan Jun

Affiliation:

Kungliga Tekniska högskolan

Start Date:

2018-09-20

End Date:

2019-10-01

Primary Classification:

10203: Bioinformatics (Computational Biology) (applications to be 10610)

Webpage:

Allocation

Abstract

Accurate reconstruction of cancer phylogeny is central to understanding progression of tumor. Prior work on phylogenetic inference has relied primarily on bulk DNA-seq data. With the advances in single cell sequencing technology, focus of research in computational cancer biology has been in regards to constructing phylogenetics tree to relate ancestral relationship between single cells. We developed a probabilistic model for joint analysis of bulk DNA-seq data and single cell RNA-seq data (scRNA-seq).