SNIC
SUPR
SNIC SUPR
Epigenetic changes in the immune system during exposure to mycobacteria
Dnr:

SNIC 2018/3-447

Type:

SNAC Medium

Principal Investigator:

Maria Lerm

Affiliation:

Linköpings universitet

Start Date:

2018-10-01

End Date:

2019-10-01

Primary Classification:

30109: Microbiology in the medical area

Secondary Classification:

30110: Immunology in the medical area

Tertiary Classification:

30107: Medical Genetics

Allocation

Abstract

Tuberculosis (TB) is a disease of global importance and we follow a line of investigation in which we map epigenetic changes in response to exposure to the bacteria that cause TB or the TB vaccine, which is an attenuated mycobacterium. We are collecting informaiton on the DNA methylome using next generation sequencing techniques, generating large datasets. Our ambition is to identify patterns, or biosignatures, in the DNA methylome of immune cells, that reflect epigenetic changes during exposure to Mycobacterium tuberculosis or other mycobacteria. We need access to the supercomputer in order to perform parallel computation using machine learning approaches.